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New investigations at the RIKEN Quantitative Biology Center have found that chemical modifications to a single protein molecule could form a temperature independent, self-sustainable oscillator . [12] Artificial repressilators could potentially aid research and treatments in fields ranging from circadian biology to endocrinology.
One of the most common forms of biological oscillation is genetic oscillation, which can take place when a transcription factor binds and represses its own promoter.This type of regulatory system is able to successfully describe the NFkB-IkB and p53-Mdm52 biological oscillating systems.
The lac operon: 1: RNA Polymerase, 2: lac repressor, 3: Promoter, 4: Operator, 5: Lactose, 6: lacZ, 7: lacY, 8: lacA. Top: The gene is essentially turned off.There is no lactose to inhibit the repressor, so the repressor binds to the operator, which obstructs the RNA polymerase from binding to the promoter and making lactase.
The goal of synthetic biology is to generate an array of tunable and characterized parts, or modules, with which any desirable synthetic biological circuit can be easily designed and implemented. [2] These circuits can serve as a method to modify cellular functions, create cellular responses to environmental conditions, or influence cellular ...
In biology, cell signaling (cell signalling in British English) is the process by which a cell interacts with itself, other cells, and the environment. Cell signaling is a fundamental property of all cellular life in prokaryotes and eukaryotes.
In 1997–1998, he spent one year at the European Molecular Biology Laboratory at Heidelberg. Afterwards, he was a postdoctoral fellow at the Rockefeller University in New York City. While working as a graduate student at Princeton he co-authored songs such as Sunday at the Lab [ 11 ] with Uri Alon .
Pseudo-response regulator (PRR) refers to a group of genes that regulate the circadian oscillator in plants. There are four primary PRR proteins (PRR9, PRR7, PRR5 and TOC1/PRR1) that perform the majority of interactions with other proteins within the circadian oscillator, and another (PRR3) that has limited function.
In molecular biology, an inducer is a molecule that regulates gene expression. [1] An inducer functions in two ways; namely: By disabling repressors. The gene is expressed because an inducer binds to the repressor. The binding of the inducer to the repressor prevents the repressor from binding to the operator.