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[10]: 280–4 Hence, a single experiment can be used to measure the logarithms of the partition coefficient (log P) giving the distribution of molecules that are primarily neutral in charge, as well as the distribution coefficient (log D) of all forms of the molecule over a pH range, e.g., between 2 and 12.
pH partition is the tendency for acids to accumulate in basic fluid compartments, and bases to accumulate in acidic compartments. The reason for this phenomenon is that acids become negatively electric charged in basic fluids, as they donate a proton. On the other hand, bases become positively electric charged in acid fluids, as they receive a ...
Fugacity and BCF relate to each other in the following equation: = [6] where Z Fish is equal to the Fugacity capacity of a chemical in the fish, P Fish is equal to the density of the fish (mass/length 3), BCF is the partition coefficient between the fish and the water (length 3 /mass) and H is equal to the Henry's law constant (Length 2 /Time 2) [6]
The n-octanol-water partition coefficient, K ow is a partition coefficient for the two-phase system consisting of n-octanol and water. [1] K ow is also frequently referred to by the symbol P, especially in the English literature. It is also called n-octanol-water partition ratio. [2] [3] [4]
A table comparing four different scales for the hydrophobicity of an amino acid residue in a protein with the most hydrophobic amino acids on the top. A number of different hydrophobicity scales have been developed. [3] [1] [7] [8] [9] The Expasy Protscale website lists a total of 22 hydrophobicity scales. [10]
Where K d is called the distribution coefficient or the partition coefficient. Concentration of X in solvent A/concentration of X in solvent B=Kď If C 1 denotes the concentration of solute X in solvent A & C 2 denotes the concentration of solute X in solvent B; Nernst's distribution law can be expressed as C 1 /C 2 = K d. This law is only ...
The partition coefficient is defined at a specified temperature and, if applicable, pH of the aqueous phase. Partition coefficients are very important in pharmacology because they determine the extent to which a substance can pass from the blood (an aqueous solution) through a cell wall which is like an organic solvent. They are usually ...
Hydrolysis as a function of pH 112: Dissociation constants in water 113: Screening test for thermal stability and stability in air 114: Viscosity of liquids 115: Surface tension of aqueous solutions: 116: Fat solubility of solid and liquid substances 117: Partition coefficient (n-octanol/water), HPLC Method 118