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Diltiazem, sold under the brand name Cardizem among others, is a nondihydropyridine calcium channel blocker medication used to treat high blood pressure, angina, and certain heart arrhythmias. [9] It may also be used in hyperthyroidism if beta blockers cannot be used. [ 9 ]
For example, as of 2006, diltiazem hydrochloride had four equivalence groups, all using the same active ingredient, but considered equivalent only within each group. [46] In order to start selling a drug promptly after the patent on innovator drug expires, a generic company has to file its ANDA well before the patent expires.
diltiazem verapamil The 8th Joint National Committee (JNC-8) recommends calcium channel blockers to be a first-line treatment either as monotherapy or in combination with thiazide -type diuretics, ACEis, or ARBs for all patients regardless of age or race.
1,3-thiazepine 1,4-thiazepine Diltiazem. 1,4-thiazepine is the seven membered ring in the middle. Thiazepines are substituted thiepins, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound. [1] Depending on the location of the nitrogen, one distinguishes 1,3-thiazepine and 1,4-thiazepine. [1]
Dihydropyridine calcium channel blockers are derivatives of 1,4-dihydropyridine that are used as L-type calcium channel blockers. [1] They are used in the treatment of hypertension.
Benzothiadiazine, the parent structure of this class of molecules. Thiazide (/ ˈ θ aɪ É™ z aɪ d /) refers to both a class of sulfur-containing organic molecules [1] and a class of diuretics based on the chemical structure of benzothiadiazine. [2]
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According to the FDA, sotalol should not be used in people with a waking heart rate lower than 50 beats per minute. [8] It should not be used in people with sick sinus syndrome, long QT syndrome, cardiogenic shock, uncontrolled heart failure, asthma or a related bronchospastic condition, or people with serum potassium below 4 meq/L. [8] It should only be used in people with a second and third ...
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