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Methotrexate-induced papular eruption appears in patients being treated with methotrexate, such as those with rheumatic disease, presenting with erythematous indurated papules, usually located on the proximal extremities. [1] It has been suggested that it may represent a cutaneous small-vessel vasculitis. [2]
Type III hypersensitivity, in the Gell and Coombs classification of allergic reactions, occurs when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response and attraction of leukocytes.
Methotrexate (green) complexed into the active site of DHFR (blue) Methotrexate is an antimetabolite of the antifolate type. It is thought to affect cancer and rheumatoid arthritis by two different pathways. For cancer, methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis.
There is an association between rheumatoid factor and more persistently active synovitis, more joint damage, greater eventual disability and arthritis. [12] [13] Other than in rheumatoid arthritis, rheumatoid factor may also be elevated in other conditions, including: Systemic lupus erythematosus (SLE) [14] [15] Sjögren syndrome [14] [15]
Illustration of a Hand affected by Rheumatoid arthritis. Rheumatoid Arthritis (RA) is an inflammatory disease that's caused by an autoimmune condition. The condition occurs when bodily cells begin to attack and target their own healthy joint tissues resulting in redness, inflammation, and pain. Patients with RA may be given antiarthritics that ...
Rheumatoid Arthritis. Hair loss from rheumatoid arthritis is uncommon, but it can happen. The autoimmune disease itself doesn’t cause hair loss, but the medications used to treat rheumatoid ...
Poison ivy. What it looks like: Poison ivy is a type of allergic contact dermatitis that is caused by the oil (urushiol oil) in the poison ivy plant, explains Karan Lal, D.O., M.S., F.A.A.D ...
Rheumatoid arthritis [2] Possibly collagen and/or citrullinated self proteins Chronic arthritis, inflammation, destruction of articular cartilage and bone Tuberculin reaction (Mantoux test) [3] Tuberculin Induration and erythema around injection site indicates previous exposure
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