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Spastic quadriplegia, also known as spastic tetraplegia, is a subset of spastic cerebral palsy that affects all four limbs (both arms and legs). Compared to quadriplegia , spastic tetraplegia is defined by spasticity of the limbs as opposed to strict paralysis .
These mutations interrupt the transport of serine from astrocytes to neurones, and across the blood brain barrier [10] L-serine is important in brain development as it is a vital component in protein synthesis, as well as being the precursor to several essential compounds, including phosphatidylserine , sphingomyelin , glycine , and D-serine .
Generally, diseases outlined within the ICD-10 codes G80-G83 within Chapter VI: Diseases of the nervous system should be included in this category. Subcategories This category has the following 9 subcategories, out of 9 total.
Spastic CP is the most common type of overall cerebral palsy, representing roughly 80% of cases. [2] Spastic CP is a permanent condition and will affect an individual across the lifespan. [5] The brain injury that causes spastic CP remains stable over time, but the way spasticity affects a person can change. [1]
Halperin-Birk syndrome (HLBKS) is a rare autosomal recessive neurodevelopmental disorder caused by a null mutation in the SEC31A gene. Signs and symptoms include intrauterine growth retardation, marked developmental delay, spastic quadriplegia with profound contractures, dysmorphism, and optic nerve atrophy with no eye fixation.
The Gross Motor Function Classification System or GMFCS is a 5 level clinical classification system that describes the gross motor function of people with cerebral palsy on the basis of self-initiated movement abilities.
Leukodystrophies are a group of hereditary diseases that are known to cause spastic hemiplegia. Brain infections that cause spastic hemiplegia are meningitis, multiple sclerosis, and encephalitis. [7] The spasticity occurs when the afferent pathways in the brain are compromised and the communication between the brain to the motor fibers is lost ...
Dyskinetic cerebral palsy could have multiple causes. The majority of the children are born at term and experience perinatal adverse events which can be supported by neuroimaging. Possible causes are perinatal hypoxic-ischaemia and neonatal shock in children born at term or near term.