Search results
Results from the WOW.Com Content Network
In recent years, spherosomes, olesomes, and oil droplets have all been grouped under the general term "lipid droplet", or LD for short. Publications on the subject have grown drastically over the last five years, [ 13 ] but there are still numerous outstanding research questions regarding spherosomes and lipid droplets.
The function of perilipin 2 involves the formation of lipid droplets, formation of fatty liver by increasing uptake of fatty acids etc. Decreased expression of perilipin 2 decreases the fatty liver while increase expression of perilipin is associated with several metabolic diseases like type 2 diabetes, insulin resistance, heart diseases.
Initially, these lipid droplets were considered to merely serve as fat depots, but since the discovery in the 1990s of proteins in the lipid droplet coat that regulate lipid droplet dynamics and lipid metabolism, lipid droplets are seen as highly dynamic organelles that play a very important role in the regulation of intracellular lipid storage ...
The lipid droplet's function is to store energy for the organism's body and is found in every type of adipocytes. They can consist of a vacuole, droplet of triglyceride, or any other blood lipid, as opposed to fat cells in between other cells in an organ. They contain a hydrophobic core and are encased in a phospholipid monolayer membrane. Due ...
CMA is involved in the removal of Chk1, a key protein for cell cycle progression and cells with impaired CMA have defective DNA repair. [26] CMA degrades lipid droplet proteins (perilipin 2 and perilipin 3). [27] Removal of these lipid droplet coat proteins by CMA precedes lipolysis and lipophagy. [27]
The laboratory also investigates lipid metabolism in human pathologies, such as cancer and neurodegenerative disease. Walther was an associate professor of cell biology at the Yale School of Medicine. [5] While at Yale, Walther positioned his laboratory at the forefront of the rapidly growing field of lipid droplet biology.
StAR-related lipid transfer domain protein 13 (STARD13) also known as deleted in liver cancer 2 protein (DLC-2) is a protein that in humans is encoded by the STARD13 gene and a member of the DLC family of proteins.
Adult T-cell leukemia/lymphoma (ATL or ATLL) is a rare cancer of the immune system's T-cells [1] [2] [3] caused by human T cell leukemia/lymphotropic virus type 1 . [4] All ATL cells contain integrated HTLV-1 provirus further supporting that causal role of the virus in the cause of the neoplasm. [ 4 ]