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MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. [5] MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2 , and functions as a pattern recognition receptor capable of detecting viruses .
RIG-I domain architecture. (A) Schematic representation of full-length RIG-I. (B) X-ray crystal structure of RNA-bound RIG-I ( ), excluding the CARD domains.The RLR receptors are members of the DEAD-box (SF2) helicase family (despite containing a DExD/H motif, rather than the DEAD motif characteristic of the family) and share a common domain architecture.
Bang Bang's current logo. This is a list of television programs currently broadcast (in first-run or reruns), scheduled to be broadcast, or formerly broadcast on Bang Bang, an Albanian television channel by DigitAlb that airs a mix of animated television series, animated and live-action films as well as live-action Albanian originals produced by DigitAlb.
At a resting state for the cell, a protein called mitofusin 2 (MFN2) is known to interact with MAVS, preventing MAVS from binding to the cytosolic proteins, such as RIG-I and MDA5. [ 7 ] [ 8 ] Upon recognition of the virus in the cytosol, mitochondria-associated ER membranes (MAM) and mitochondria will become physically tethered by MFN2 and RIG ...
Portokalli (transl. Orange) is an Albanian weekly night sketch comedy and variety show that airs on Top Channel. [1] It began airing on 31 December 2003 [2] and it includes stand-up comedy and live music which makes it similar to the American late-night live television show Saturday Night Live.
American Dragon: Jake Long (Dragoi amerikan: Xhek Long) [2]; Chloe's Closet (Dollapi i Kloes) [3]; Glitch Techs (Teknikë teknologjikë); Justice League (Skuadra e drejtësisë) [4] ...
YouTube is an American social media and online video sharing platform owned by Google. YouTube was founded on February 14, 2005, by Steve Chen, Chad Hurley, and Jawed Karim, three former employees of PayPal. Headquartered in San Bruno, California, it is the second-most-visited website in the world, after Google Search.
The Albanian Wikipedia (Albanian: Wikipedia Shqip) is the Albanian language edition of Wikipedia started on 12 October 2003. As of 15 January 2025, the Wikipedia has 101,316 articles and is the 73rd-largest Wikipedia.