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Reelin's name comes from the abnormal reeling gait of reeler mice, [17] which were later found to have a deficiency of this brain protein and were homozygous for mutation of the RELN gene. The primary phenotype associated with loss of reelin function is a failure of neuronal positioning throughout the developing central nervous system (CNS).
DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis. It docks to the intracellular part of the Reelin very low density lipoprotein receptor ( VLDLR ) and apoE receptor type 2 ( ApoER2 ) and becomes tyrosine-phosphorylated following binding of Reelin to ...
Through interactions with one of its ligands, reelin, ApoER2 plays an important role in embryonic neuronal migration and postnatal long-term potentiation. Another LDL family receptor, VLDLR, also interacts with reelin, and together these two receptors influence brain development and function. Decreased expression of ApoER2 is associated with ...
The examples include: Double knockout of VLDLR and ApoER2 receptors; [5] Double knockout of Src and Fyn kinases. [6] Cre-loxP recombination mice model that lacks Crk and CrkL in most neurons. [7] Was used to show that Crk/CrkL lie downstream of DAB1] in the reelin signaling pathway. Scrambler mouse; Brain slices of wildtype and reeler mice
Here’s the story, of a woman named Taylor, who just wanted to get the line right. Christine Taylor remembers the infamous “Sure, Jan” scene from The Brady Bunch Movie all too well — and ...
Was one of the big three spreadsheets (the others being Lotus 123 and Excel). EasyOffice EasySpreadsheet – for MS Windows. No longer freeware, this suite aims to be more user friendly than competitors. Framework – for MS Windows. Historical office suite still available and supported. It includes a spreadsheet.
The product of the reeler gene in mouse is reelin, a large extracellular protein secreted by pioneer neurons that coordinates cell positioning during neurodevelopment. [1] F-spondin and mindin are a family of matrix-attached adhesion molecules that share structural similarities and overlapping domains of expression. Both F-spondin and mindin ...
Thomae's function: is a function that is continuous at all irrational numbers and discontinuous at all rational numbers. It is also a modification of Dirichlet function and sometimes called Riemann function. Kronecker delta function: is a function of two variables, usually integers, which is 1 if they are equal, and 0 otherwise.