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An organ-on-a-chip (OOC) is a multi-channel 3-D microfluidic cell culture, integrated circuit (chip) that simulates the activities, mechanics and physiological response of an entire organ or an organ system. [1] [2] It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS.
Schematic of the Emulate liver-chip [4] Emulate's Organs-on-Chips technology has been used to recreate the function of a variety of different organs, including the liver, intestine, brain, kidney, and lung. [5] The company's Organ-Chips are about the size of a AA battery and feature two fluidic channels that create the flow of blood and other ...
Schematic drawing of a lung-on-a-chip. The membrane in the middle can be stretched by vacuum in the two side chambers. Lung-on-a-chip (LoC), also known as Lung Chips, are micro- and millifluidic organ-on-a-chip devices designed to replicate the structure and function of the human lung, mimicking the breathing motions and fluid dynamics that occur during inhalation and exhalation. [1]
A prominent example of an intestine-on-a-chip system relying on architectural cues is the homeostatic mini-intestines by Nikolaev et al. [24] They use microfabricated intestine-on-a-chip devices with a hydrogel chamber. The collagen-Matrigel-mix hydrogel is laser-ablated to generate a microchannel for a tubular intestinal lumen with crypt ...
An organoid is a miniaturised and simplified version of an organ produced in vitro in three dimensions that mimics the key functional, structural, and biological complexity of that organ. [1] It is derived from one or a few cells from a tissue , embryonic stem cells , or induced pluripotent stem cells , which can self-organize in three ...
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Pages in category "System on a chip" The following 38 pages are in this category, out of 38 total. This list may not reflect recent changes. ...
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