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MSI-H status raises the possibility of Lynch syndrome, but MSI-H can also occur in patients without Lynch Syndrome and confirmation of Lynch Syndrome requires testing germline DNA. Lynch syndrome is associated with MSI and increases the risk for colon, endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and ...
Under the name constitutional mismatch repair-deficiency (CMMR-D), it has been mapped to MLH1, MSH2, MSH6 or PMS2. [2] Monoallelic mutations of these genes are observed in the condition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer, while biallelic mutations are observed in CMMR-D. [3] People expressing the HNPCC (which itself is considered autosomal dominant) trait are ...
DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.
DNA mismatch repair protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2.MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex.
The default map image, without "Image:" or "File:" image1 = Relief map of Texas.png An alternative map image, usually a relief map, which can be displayed via the relief or AlternativeMap parameters; top = 36.8 Latitude at top edge of map, in decimal degrees; bottom = 25.5 Latitude at bottom edge of map, in decimal degrees; left = -106.9 ...
Texas rank U.S. rank Metropolitan area Metropolitan division Population (2023 est.) 1 4 Dallas–Fort Worth 8,100,037: 2 5 Houston 7,510,253: 3 24 San Antonio 2,703,999: 4 26 Austin 2,473,275: 5 65 McAllen 898,471: 6 68 El Paso 873,331: 7 110 Killeen-Temple 501,333: 8 121 Corpus Christi 448,323: 9 127 Brownsville-Harlingen 426,710: 10 140 ...
As of 2023, the largest of these is the Dallas-Fort Worth, TX-OK CSA, encompassing the area around the twin cities of Dallas and Fort Worth in the northern part of the state. Owing to its large area and population - the second-highest amongst the 50 states in both respects [2] [3] - Texas contains the most statistical areas of any state.
Area 1: Panhandle/High Plains Wildlife District [1] [2] includes five WMAs; Area 2: Prairies and Lakes [3] Area 3: Pineywoods [4] Area 4: Gulf Coast [5] Area 5: South Texas Plains [6] Area 6: Hill Country [7] Area 7: Big Bend Country [8] There is some confusion as there are also listed eight Wildlife Management Areas [9] that roughly coincide ...