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MSI-H tumors result from MSI of greater than 30% of unstable MSI loci (>2 or more of the 5 loci). MSI-L tumors result from less than 30% of unstable MSI biomarkers. MSI-L tumors are classified as tumors of alternative etiologies. Several studies demonstrate that MSI-H patients respond best to surgery alone, rather than chemotherapy and surgery ...
Under the name constitutional mismatch repair-deficiency (CMMR-D), it has been mapped to MLH1, MSH2, MSH6 or PMS2. [2] Monoallelic mutations of these genes are observed in the condition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer, while biallelic mutations are observed in CMMR-D. [3] People expressing the HNPCC (which itself is considered autosomal dominant) trait are ...
DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.
Mass spectrometry imaging (MSI) is a technique used in mass spectrometry to visualize the spatial distribution of molecules, as biomarkers, metabolites, peptides or proteins by their molecular masses. After collecting a mass spectrum at one spot, the sample is moved to reach another region, and so on, until the entire sample is scanned.
Name used in the default map caption; image = USA Texas location map.svg The default map image, without "Image:" or "File:" image1 = Relief map of Texas.png An alternative map image, usually a relief map, which can be displayed via the relief or AlternativeMap parameters; top = 36.8 Latitude at top edge of map, in decimal degrees; bottom = 25.5 ...
DNA mismatch repair protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2.MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex.
Texas rank U.S. rank Metropolitan area Metropolitan division Population (2023 est.) 1 4 Dallas–Fort Worth 8,100,037: 2 5 Houston 7,510,253: 3 24 San Antonio 2,703,999: 4 26 Austin 2,473,275: 5 65 McAllen 898,471: 6 68 El Paso 873,331: 7 110 Killeen-Temple 501,333: 8 121 Corpus Christi 448,323: 9 127 Brownsville-Harlingen 426,710: 10 140
As of 2023, the largest of these is the Dallas-Fort Worth, TX-OK CSA, encompassing the area around the twin cities of Dallas and Fort Worth in the northern part of the state. Owing to its large area and population - the second-highest amongst the 50 states in both respects [2] [3] - Texas contains the most statistical areas of any state.