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Van Andel Institute (VAI) is a 501(c)(3) nonprofit biomedical research and science education organization in Grand Rapids, Michigan. VAI was founded by Jay and Betty Van Andel in 1996. [1] The institute's research focuses on cancer epigenetics and Parkinson's disease. Its educational efforts support teacher development and science education ...
Cancer-related metabolic changes lead to locus-specific recoding of epigenetic marks. Cancer epigenetics can be precisely reprogramed by cellular metabolism through 1) dose-responsive modulation of cancer epigenetics by metabolites; 2) sequence-specific recruitment of metabolic enzymes; and 3) targeting of epigenetic enzymes by nutritional ...
The basic research division includes programs in cancer regulatory networks and cancer genetics and epigenetics. Programs in the disease-specific division focus on breast cancer, hematological cancer, prostate cancer, and neuro-oncology. The population science division includes cancer epidemiology and prevention, control, and disparities.
In May 2010 developmental biologist Christof Niehrs (formerly at the German Cancer Research Center, DKFZ) was appointed as the institute's founding director. The institute was then named "Institute of Molecular Biology" and the institute's research focus on developmental biology, epigenetics, and DNA repair was set. [4]
Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
He was a featured scientist on the PBS NOVA television program on epigenetics in 2007 entitled Ghost in Your Genes. [34] He was the inaugural recipient of the Epigenetic Medicine Award. [35] In 2009, Jirtle received the STARS Lecture Award in Nutrition and Cancer from the National Cancer Institute. [36] Dr.
While there is still a lot of work that needs to be done regarding the epigenetic modifications of specific cancers at various steps in tumor development, there is a general understanding of epigenetic modifications in genes that lead to abnormal expression and various types of cancer. These epigenetic biomarkers are being considered in ...
Center for Cancer Training; Center for Global Health; Center for Strategic Scientific Initiatives; In the 1990s, the Unconventional Innovation Program was created to integrate interdisciplinary technology research with biological applications. It was reorganized in 2004 as the CSSI. [26] Center to Reduce Cancer Health Disparities; Center for ...