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18205 Ensembl ENSG00000185652 ENSMUSG00000049107 UniProt P20783 P20181 RefSeq (mRNA) NM_001102654 NM_002527 NM_001164034 NM_001164035 NM_008742 RefSeq (protein) NP_001096124 NP_002518 NP_001157506 NP_001157507 NP_032768 Location (UCSC) Chr 12: 5.43 – 5.52 Mb Chr 6: 126.08 – 126.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Neurotrophin-3 is a protein that in humans is ...
The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) [5] [6] before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. [7] [8] p75NTR is a neurotrophic factor receptor.
Whereas neurotrophic factors within the neurotrophin family commonly have a protein tyrosine kinase receptor (Trk), Neurotrophin-3 (NT-3) has the unique receptor, TrkC. [8] In fact, the discovery of the different receptors helped differentiate scientists' understanding and classification of NT-3. [ 13 ]
Tropomyosin receptor kinase C (TrkC), [5] also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene. [6] TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3).
Neurotrophin-3, or NT-3, is a neurotrophic factor, in the NGF-family of neurotrophins. It is a protein growth factor that has activity on certain neurons of the peripheral and central nervous system ; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses .
The common ligands of trk receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous system. [3] The binding of these molecules is highly specific. Each type of neurotrophin has different binding affinity toward its corresponding Trk receptor. The activation of Trk receptors by neurotrophin binding may ...
p75 is a low affinity neurotrophin receptor, to which all neurotrophins bind. It is a member of the tumour necrosis super family. In some contexts, the phrase "x" only applies to this receptor. [1] The Trk family include TrkA, TrkB, and TrkC, and will only bind with specific neurotrophins, but with a much higher affinity. The Trks mediate the ...
4803 18049 Ensembl ENSG00000134259 ENSMUSG00000027859 UniProt P01138 P01139 RefSeq (mRNA) NM_002506 NM_001112698 NM_013609 RefSeq (protein) NP_002497 NP_001106168 NP_038637 Location (UCSC) Chr 1: 115.29 – 115.34 Mb Chr 3: 102.38 – 102.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the ...