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Ribosomes are the macromolecular machines that are responsible for mRNA translation into proteins. The eukaryotic ribosome, also called the 80S ribosome, is made up of two subunits – the large 60S subunit (which contains the 25S [in plants] or 28S [in mammals], 5.8S, and 5S rRNA and 46 ribosomal proteins) and a small 40S subunit (which contains the 18S rRNA and 33 ribosomal proteins). [6]
A ribosomal protein (r-protein or rProtein [1] [2] [3]) is any of the proteins that, in conjunction with rRNA, make up the ribosomal subunits involved in the cellular process of translation. E. coli , other bacteria and Archaea have a 30S small subunit and a 50S large subunit, whereas humans and yeasts have a 40S small subunit and a 60S large ...
51119 66711 Ensembl ENSG00000126524 ENSMUSG00000025337 UniProt Q9Y3A5 P70122 RefSeq (mRNA) NM_016038 NM_023248 RefSeq (protein) NP_057122 NP_075737 Location (UCSC) Chr 7: 66.99 – 67 Mb Chr 5: 130.27 – 130.28 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ribosome maturation protein SBDS is a protein that in humans is encoded by the SBDS gene. An alternative transcript has been ...
In humans, the NPM1 gene is located on the long arm of chromosome 5 (5q35). The gene spans 23 kb and contains 12 exons. Three transcript variants have been described. The longest isoform (294 amino acids long), encoded by transcript variant 1, is the major and the most well studied isoform of Nucleophosmin.
23246 12181 Ensembl ENSG00000261236 ENSG00000285301 ENSMUSG00000022557 UniProt Q14137 P97452 RefSeq (mRNA) NM_015201 NM_013481 RefSeq (protein) NP_056016 NP_038509 Location (UCSC) Chr 8: 144.26 – 144.29 Mb Chr 15: 76.34 – 76.36 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ribosome biogenesis protein BOP1 is a protein that in humans is encoded by the BOP1 gene. It is a WD40 ...
Overview of eukaryotic messenger RNA (mRNA) translation Translation of mRNA and ribosomal protein synthesis Initiation and elongation stages of translation involving RNA nucleobases, the ribosome, transfer RNA, and amino acids The three phases of translation: (1) in initiation, the small ribosomal subunit binds to the RNA strand and the initiator tRNA–amino acid complex binds to the start ...
Cancer cells have irregularly shaped, large nucleoli, which may correspond ribosomal gene transcription up-regulation, and hence high cell proliferation. Oncogenes, like c-Myc, can upregulate rDNA transcription in a direct and indirect fashion. Tumor suppressors like Rb and p53, on the other hand, can suppress ribosome biogenesis. Additionally ...
40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene. [5] [6] [7] Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.
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