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Cell damage (also known as cell injury) is a variety of changes of stress that a cell suffers due to external as well as internal environmental changes. Amongst other causes, this can be due to physical, chemical, infectious, biological, nutritional or immunological factors. Cell damage can be reversible or irreversible.
Metaplasia occurs when a cell of a certain type is replaced by another cell type, which may be less differentiated. It is a reversible process thought to be caused by stem cell reprogramming. Stem cells are found in epithelia and embryonic mesenchyme of connective tissue. A prominent example of metaplasia involves the changes associated with ...
Classified as a "conversion disorder" by the DSM-IV, a psychogenic disease is a condition in which mental stressors cause physical symptoms matching other disorders. The manifestation of physical symptoms without biologically identifiable cause results from disruptions in normal brain function due to psychological stress.
Psychosocial short stature (PSS) is a growth disorder that is observed between the ages of 2 and 15, caused by extreme emotional deprivation or stress.. The symptoms include decreased growth hormone (GH) and somatomedin secretion, very short stature, weight that is inappropriate for the height, and immature skeletal age.
Stress ulceration is a single or multiple fundic mucosal ulcers that causes upper gastrointestinal bleeding, and develops during the severe physiologic stress of serious illness. It can also cause mucosal erosions and superficial hemorrhages in patients who are critically ill, or in those who are under extreme physiologic stress, causing blood ...
Traumatic events or any type of shock to the body can cause an acute stress response disorder (ASD). The extent to which one experiences ASD depends on the extent of the shock. If the shock was pushed past a certain extreme after a particular period in time ASD can develop into what is commonly known as Post-traumatic stress disorder (PTSD). [11]
Frequent stress: the magnitude and frequency of response to stress is what determines the level of allostatic load which affects the body. Failed shut-down: the inability of the body to shut off while stress accelerates and levels in the body exceed normal levels, for example, elevated blood pressure.
Furthermore, different forms of cellular stress can cause protein misfolding and aggregation leading to proteotoxicity. [9] Tumor microenvironment stress leads to canonical and noncanonical endoplasmic stress (ER) responses, which trigger autophagy and are engaged during proteotoxic challenges to clear unfolded or misfolded proteins and damaged ...