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2'-O-methylation (2'-O-Me) is a common nucleotide epitranscriptomics modification of ribosomal RNA (rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. [ 1 ] The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the ...
An unusual guide snoRNA U85 that functions in both 2′-O-ribose methylation and pseudouridylation of small nuclear RNA (snRNA) U5 has been identified. [14] This composite snoRNA contains both C/D and H/ACA box domains and associates with the proteins specific to each class of snoRNA (fibrillarin and Gar1p, respectively).
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U25 is found in gene clusters in plants [2] and within the U22 snoRNA host gene (UHG) in mammals. [3] U25 is thought to as a 2'-O-ribose methylation guide for ribosomal RNA. This RNA has also been named snoRNA R73 in some plants.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] [2] In humans U29 and several other snoRNAs (U22 and U25-U31) are located in the introns of the same gene (called UHG for U22 host gene). [3] [4] U29 is proposed to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA ...
HBII-108 is the human orthologue of the mouse MBII-108 [2] and is predicted to guide 2'O-ribose methylation of the small subunit (SSU) ribosomal RNA (rRNA), 18S, on position G683. [3] In the human genome snoRNA HBII-108 is located in the introns of the gene nucleostemin (NS), along with another snoRNA HBII-210.
This family functions to direct site-specific 2'-O-methylation of substrate RNAs. [1] This snoRNA was originally cloned from human HeLa cells during a screen for intron encoded snoRNAs. [2] It is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue A99 3
This snoRNA was originally cloned from HeLa cells and experimentally verified by northern blotting. [2] SNORD48 is predicted to guide the 2'O-ribose methylation of 28S rRNA C2279. [ 3 ] In the human genome this snoRNA is located in the introns of the same host gene (C6orf48) as another C/D box snoRNA U52 (also known as SNORD52).
U46 is encoded in intron 2 of the ribosomal protein S8 gene in human, and is hypothesised to guide methylation of 2'-O-ribose residues on 28S ribosomal RNA (rRNA). [2] [3] The homologue of this snoRNA in Arabidopsis thaliana is called snoZ153. [4] Some human U40 sequences have been annotated in the sequence databases (Genbank) as U46.
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