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2'-O-methylation (2'-O-Me) is a common nucleotide epitranscriptomics modification of ribosomal RNA (rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. [ 1 ] The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the ...
An unusual guide snoRNA U85 that functions in both 2′-O-ribose methylation and pseudouridylation of small nuclear RNA (snRNA) U5 has been identified. [14] This composite snoRNA contains both C/D and H/ACA box domains and associates with the proteins specific to each class of snoRNA (fibrillarin and Gar1p, respectively).
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U25 is found in gene clusters in plants [2] and within the U22 snoRNA host gene (UHG) in mammals. [3] U25 is thought to as a 2'-O-ribose methylation guide for ribosomal RNA. This RNA has also been named snoRNA R73 in some plants.
These sequences base-pair with nucleotides in the target rRNA to direct their methylation. [ 3 ] sR8 RNA operates alongside protein components in a ribonucleoprotein (RNP) complex. sR8 is able to guide the methylation of targets found within structured stem-loops , which implies that a component of the complex is able to unwind such structures.
Most of the members of the C/D box family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] SNORD100 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue G436.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] This snoRNA was originally cloned from HeLa cells and expression verified by northern blotting. [2] It is predicted to guide 2'O-ribose methylation of ribosomal RNA (rRNA) 28S at residue C3866.
This family functions to direct site-specific 2'-O-methylation of substrate RNAs. [1] This snoRNA was originally cloned from human HeLa cells during a screen for intron encoded snoRNAs. [2] It is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue A99 3
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] SNORD94 is predicted to guide the 2'O-ribose methylation of C62 of the snRNA U6 .