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H&E stain of fundic gland polyp showing shortening of the gastric pits with cystic dilatation. The development of polyps depends on the underlying disorder. [17] In sporadic cases of FGPs, more than 90% of patients have activating mutations in the β-catenin gene, so that they may be considered "neoplastic" polyps. [18]
A fundic gland polyp is a type of polyp, found in the fundus of the stomach. Fundic gland polyps are found in 0.8 to 1.9% of patients who undergo esophagogastroduodenoscopy, and are more common in middle-aged women. [2] The risk of malignancy is very low or none, when sporadic. [3]
Fundic gland polyposis is a medical syndrome where the fundus and the body of the stomach develop many fundic gland polyps. Pernicious anemia is caused when damaged parietal cells fail to produce the intrinsic factor necessary for the absorption of vitamin B12. This is the most common cause of vitamin B12 deficiency.
Diagram showing gastric pits (13) gastric glands (12) lamina propria (10) epithelium (11) Histology of normal fundic mucosa. Fundic glands are simple, branched tubular glands that extend from the bottom of the gastric pits to the muscularis mucosae; the more distinctive cells are parietal cells. H&E stain. Histology of normal antral mucosa.
Hyperplastic polyp of the stomach Stomach: Elongated, tortuous, and cystic foveolae separated by edematous and inflamed stroma. [4] Gastric hyperplastic polyposis Fundic gland polyp: Fundus of stomach: Cystically dilated glands lined by chief cells, parietal cells and mucinous foveolar cells. [5] Very low or none, when sporadic. [6] Fundic ...
Histopathology of fundic mucosa with atrophy. H&E 10x; square 20x. Fundic-corporal gastric mucosa with extensive loss of gastric glands, partially replaced by pseudo-pyloric metaplasia.
Immunofluorescence staining pattern of gastric parietal antibodies on a stomach section Parietal cells are part of fundic gland polyps (here shown in high magnification). [9] Peptic ulcers can result from over-acidity in the stomach. Antacids can be used to enhance the natural tolerance of the gastric lining.
A gastric chief cell, peptic cell, or gastric zymogenic cell is a type of gastric gland cell that releases pepsinogen and gastric lipase. It is the cell responsible for secretion of chymosin (rennin) in ruminant animals and some other animals. [ 1 ]
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