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56480 Ensembl ENSG00000183735 ENSMUSG00000020115 UniProt Q9UHD2 Q9WUN2 RefSeq (mRNA) NM_013254 NM_019786 RefSeq (protein) NP_037386 NP_062760 Location (UCSC) Chr 12: 64.45 – 64.5 Mb Chr 10: 121.38 – 121.42 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse TBK1 (TANK-binding kinase 1) is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. It is ...
The TBK1, [36] SQSTM1, [37] and OPTN [38] genes are involved in producing a maturing autophagosome during autophagy. In 2016, it was observed that mutations in the TBK1 protein contributed to formation of the disease. [39] Since the TBK1 protein is haploinsufficient, meaning mutations in the gene result in no protein production. [36]
Upon activation, STING stimulates TBK1 activity to phosphorylate IRF3 or STAT6. Phosphorylated IRF3s and STAT6s dimerize, and then enter nucleus to stimulate expression of genes involved in host immune response, such as IFNB, CCL2, CCL20, etc. [8] [23] Several reports suggested that STING is associated with the activation of selective autophagy ...
The unique 2’-5’ phosphodiester bond may be advantageous because it is less susceptible to degradation caused by 3’-5’ phosphodiesterases. Other advantages of the unique 2’-5’ linkage may be that cGAMP is able to bind multiple allelic variants of STING found in the human population, while other CDNs, composed of only 3’-5 ...
TBK1 may refer to: TANK-binding kinase 1, an enzyme; IkappaB kinase, an enzyme This page was last edited on 30 December 2019, at 15:16 (UTC). Text is available under ...
NEDD4-1, an E3 ligase that recognises PTEN for degradation is up-regulated by the PI3K pathway. Therefore, when Akt is activated, PTEN is further repressed in a positive feedback loop. [23] The pathway is also controlled by protein phosphatase 2A (PP2A), which dephosphorylates Akt at Thr308 and phosphatase PHLPP dephosphorylates Akt at Ser473. [3]
56489 Ensembl ENSG00000263528 ENSMUSG00000042349 UniProt Q14164 Q9R0T8 RefSeq (mRNA) NM_001193321 NM_001193322 NM_014002 NM_019777 RefSeq (protein) NP_001180250 NP_001180251 NP_054721 NP_062751 Location (UCSC) Chr 1: 206.47 – 206.5 Mb Chr 1: 131.18 – 131.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Inhibitor of nuclear factor kappa-B kinase subunit epsilon also known as I ...
Important in protein degradation. In the late 1990s, it was recognized that phosphorylation of some proteins causes them to be degraded by the ATP-dependent ubiquitin /proteasome pathway. These target proteins become substrates for particular E3 ubiquitin ligases only when they are phosphorylated.