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In ICSI a magnification of x400 is used, while in IMSI an amplification of x6000 to x10,000 is used, increasing the magnification by a factor of 15. This allows the sperm to be examined in greater detail, including the nucleus which contains the sperm's genetic material.
Live birth rate are significantly higher with progesterone to assist implantation in ICSI cycles. [24] Also, addition of a GNRH agonist has been estimated to increase success rates. [24] [25] Ultra-high magnification sperm injection (IMSI) has no evidence of increased live birth or miscarriage rates compared to standard ICSI. [26]
Although the pregnancy was successful, it was later determined that the fertilisation occurred in vivo (in the body). [3] Miriam Menkin was the first to extract an intact fertilised egg. [4] In 1948, John Rock and Miriam Menkin retrieved over 800 oocytes, of which 138 were exposed to spermatozoa in vitro.
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Pregnancy rate is the success rate for getting pregnant.It is the percentage of all attempts that leads to pregnancy, with attempts generally referring to menstrual cycles where insemination or any artificial equivalent is used, which may be simple artificial insemination (AI) or AI with additional in vitro fertilization (IVF).
As a result of the 1992 Fertility Clinic Success Rate and Certification Act, the CDC is required to publish the annual ART success rates at U.S. fertility clinics. [29] Assisted reproductive technology procedures performed in the U.S. has over than doubled over the last 10 years, with 140,000 procedures in 2006, [ 30 ] resulting in 55,000 births.
Gestational age: 3 weeks and 0 days until 3 weeks and 6 days old. 22–28 days from last menstruation. Embryonic age: Week nr 2. 1 week old. 8–14 days from fertilization.
In order to optimise pregnancy rates, there is significant evidence that a morphological scoring system is the best strategy for the selection of embryos. [60] Since 2009 where the first time-lapse microscopy system for IVF was approved for clinical use, morphokinetic scoring systems has shown to improve to pregnancy rates further. [61]