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Rodent cocktail is an anesthetic mixture used for rodents in research. The injectable, clear liquid is a mixture of ketamine, xylazine, and acepromazine. [1] The ratio used depends on the species of rodent. This mixture is often preferred by researchers because of its low mortality in rodents, its relatively quick recovery time (one hour after ...
Furthermore, anesthesia aims to minimize the surgical stress response. [2] In addition, certain diagnostic procedures require anesthesia, notably stomach or airway endoscopy, bone marrow sampling, and occasionally ultrasound. Aggressive animals may require anesthesia in order to handle and perform a physical exam or obtain blood for testing.
Rodents have been employed in biomedical experimentation from the 1650s. [1] Rodent studies up to the early 19th century were mainly physiological or toxicological.The first rodent behavioral study was carried out in 1822, a purely observational study [2], while quantitative rodent behavioral testing began in the late 19th century [1] [2].
Xylazine is a common veterinary drug used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle, and other mammals. [2] In veterinary anesthesia, it is often used in combination with ketamine. Veterinarians also use xylazine as an emetic, especially in cats. [4] Drug interactions vary with different animals.
In dogs, methoxyflurane anesthesia causes a moderate decrease in blood pressure with minimal changes in heart rate, and no significant effect on blood sugar, epinephrine, or norepinephrine. Bleeding and increased arterial partial pressure of carbon dioxide (PaCO 2 ) both induce further decreases in blood pressure, as well as increases in blood ...
The terms animal testing, animal experimentation, animal research, in vivo testing, and vivisection have similar denotations but different connotations.Literally, "vivisection" means "live sectioning" of an animal, and historically referred only to experiments that involved the dissection of live animals.
Individual dogs of any breed can have a profound reaction characterized by hypotension, especially if there is an underlying heart problem. In giant-breed dogs and sighthounds , the sedative effects of acepromazine may last for 12–24 hours, which is much longer than the usual 3–4 hours.
Pet rats are typically variants of the species brown rat, but black rats and giant pouched rats are also sometimes kept. Pet rats behave differently from their wild counterparts depending on how many generations they have been kept as pets. [20] Pet rats do not pose any more of a risk of zoonotic diseases than pets such as cats or dogs. [21]