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Asciminib, sold under the brand name Scemblix, is a medication used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). [ 5 ] [ 7 ] [ 8 ] Asciminib is a protein kinase inhibitor .
It has had a phase 1 clinical trial for Leukemias (Ph+ CML With T315I Mutation). [38] It is in a phase 1 clinical trial of combination therapy for metastatic breast cancer. [39] Asciminib (ABL001) is an inhibitor of the Abelson kinase targeting the myristoyl pocket to allosterically inhibit the enzyme. [40]
The American Cancer Society estimates that in 2014, about 5,980 new cases of chronic myeloid leukemia were diagnosed, and about 810 people died of the disease. This means that a little over 10% of all newly diagnosed leukemia cases will be chronic myeloid leukemia. The average risk of a person getting this disease is 1 in 588.
In aCML many clinical features (splenomegaly, myeloid predominance in the bone marrow with some dysplastic features but without a differentiation block) and laboratory abnormalities (myeloid proliferation, low leukocyte alkaline phosphatase values) suggest the diagnosis of chronic myelogenous leukemia (CML).
Accelerated phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which the disease is progressing. [1] Symptoms
Sex is correlated with the prevalence of certain mental disorders, including depression, anxiety and somatic complaints. [1] For example, women are more likely to be diagnosed with major depression, while men are more likely to be diagnosed with substance abuse and antisocial personality disorder. [1]
Monocytosis present for ≥3 months and other causes of monocytosis have been ruled out; WHO defined CMML has two main subsets, CMML-1 and CMML-2. CMML-1 is diagnosed if myeloblasts, monoblasts and promonocytes are <5% of peripheral blood and <10% of bone marrow. CMML-2 is diagnosed if: Myeloblasts, monoblasts or promonocytes are 5-19% in blood, or
The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]