Ads
related to: prochiral ketonesebay.com has been visited by 1M+ users in the past month
Search results
Results from the WOW.Com Content Network
Enantioselective ketone reductions convert prochiral ketones into chiral, non-racemic alcohols and are used heavily for the synthesis of stereodefined alcohols. [1]Carbonyl reduction, the net addition of H 2 across a carbon-oxygen double bond, is an important way to prepare alcohols.
The Corey–Itsuno reduction, also known as the Corey–Bakshi–Shibata (CBS) reduction, is a chemical reaction in which a prochiral ketone is enantioselectively reduced to produce the corresponding chiral, non-racemic alcohol.
The aluminium based Meerwein–Ponndorf–Verley reduction can be performed on prochiral ketones leading to chiral alcohols. The three main ways to achieve the asymmetric reduction is by use of a chiral alcohol hydride source, use of an intramolecular MPV reduction, or use of a chiral ligand on the aluminium alkoxide.
In stereochemistry, prochiral molecules are those that can be converted from achiral to chiral in a single step. [1] [2] An achiral species which can be converted to a chiral in two steps is called proprochiral. [2] If two identical substituents are attached to an sp 3-hybridized atom, the descriptors pro-R and pro-S are used to distinguish ...
And the oxazaborolidines were found to catalyze the rapid and highly enantioselective reduction of prochiral ketones in the presence of BH3THF. This enantioselective reduction of achiral ketones with catalytic oxazaborolidine is called Corey–Bakshi–Shibata reduction or CBS reduction. [28] [29] Corey-Bakshi-Shibata Reduction (CBS Reduction)-2
Barbas' collaborator List also extended the reaction to asymmetric prochiral ketones: List and Notz also revealed that proline and 5,5-dimethyl thiazolidinium-4-carboxylate appeared to be optimal catalysts within a large group of screened amines. [14] In 2002 the Macmillan group demonstrated a proline-catalyzed aldol reaction between aldehydes ...
The formed ArM can catalyze the reduction of prochiral ketones. Taking advantages of protein evolvability, different mutants of streptavidin can achieve different stereoselectivity. Throughout the years, many streptavidin-based enzymes were developed, enabling catalysis of very complex transformations in water, under ambient conditions.
Most alkenes are prochiral, and their hydrocyanation generates chiral nitriles. Conventional hydrocyanation catalysts, e.g. Ni(P(OR) 3) 4, catalyse the formation of racemic mixtures. When however the supporting ligands are chiral, the hydrocyanation can be highly enantioselective.
Ads
related to: prochiral ketonesebay.com has been visited by 1M+ users in the past month