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Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity. [4] [6] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant. [4]
Bupropion, when used for treating long-term weight gain over six to twelve months, results in an average weight loss of 2.7 kilograms (6.0 lb) over placebo. [74] This is not much different from the weight loss produced by several other weight-loss medications such as sibutramine or orlistat . [ 74 ]
An FDA-approved weight loss medication, naltrexone-bupropion is generally considered effective and safe to use. You may experience side effects like dizziness, mood changes, trouble sleeping, and ...
Over the years, several studies and meta-analyses have found that people who use bupropion to treat depression tend to gain less weight than their peers, with some people prescribed this ...
Weight loss drugs have been developed since the early twentieth century, and many have been banned or withdrawn from the market due to adverse effects, including deaths; other drugs proved ineffective. Although many earlier drugs were stimulants such as amphetamines, in the early 2020s, GLP-1 receptor agonists became popular for weight loss.
A small double-blind study found that, compared to placebo, bupropion actually increased self-reported feelings of desire and frequency of sexual activity in men with SSRI-induced sexual dysfunction.
Vyvanse (lisdexamfetamine) – a pro-drug stimulant used to treat attention deficit hyperactivity disorder and binge eating disorder; Vyvanse is converted into Dexedrine in vivo; Viibryd – an antidepressant of the serotonin modulator and stimulators class; Vivactil (protriptyline) an antidepressant also used in the treatment of nerve pain
Contrave: This medication combines bupropion (an antidepressant) and naltrexone (a drug to treat alcohol and opioid dependence) to help control appetite and cravings while increasing metabolism.
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