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Mouse Genome Informatics (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory, with funding by the National Human Genome Research Institute (NHGRI), the National Cancer Institute (NCI), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [1]
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As the queries were attributed by AOL to particular user numerically identified accounts, an individual could be identified and matched to their account and search history. [1] The New York Times was able to locate an individual from the released and anonymized search records by cross referencing them with phonebook listings. [ 2 ]
The sale of mouse animal models began in 1933 with early sales to the United States Public Health Service and The Jackson Laboratory now provides a high proportion of the mice used in biomedical research [16] In particular, the C57BL/6J strain, which is widely used and cited is maintained at The Jackson Laboratory.
MMHCdb allows researchers to search for PDX models by such parameters as cancer site, diagnosis, genomic properties of the engrafted human tumor, and model treatment response. Fig. 3 shows the output of a search for PDX models whose engrafted tumors have amplified KRAS, the TP53 A159V mutation, a deletion of the ALB gene, and high KIT expression.
Most strains of nude mice are slightly "leaky" and do have a few T cells, especially as they age. In addition, knockout mice with more complete defects in the immune system have been constructed (e.g. RAG1 and RAG2 knockout mice). For these reasons, nude mice are less popular in research today.
The name BALB is a portmanteau of "Bagg" and "Albino." From 1920, the progeny of the original colony were systematically inbred , sibling to sibling, for 26 generations over 15 years. During this time, the colony passed through the care of a number of scientists, including C.C. Little and E.C. MacDowell at the Carnegie Institution of Washington ...