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Homodimeric alpha chains (IL2RA) result in low-affinity receptor (Kd ~10−8M) with no signalling ability, while dimeric beta and gamma chains produce a medium-affinity receptor (Kd ~10−9M). Moreover, CD25 is an exclusive subunit that entirely binds IL-2, while CD132 binds the shared γc family cytokines (IL-4, IL-7, IL-9, IL-15 and IL-21 ...
CD25 deficiency or interleukin 2 receptor alpha deficiency is an immunodeficiency disorder associated with mutations in the interleukin 2 receptor alpha (CD25) (IL2RA) gene. The mutations cause expression of a defective α chain or complete absence thereof, an essential part of high-affinity interleukin-2 (IL-2) receptors.
IL-2 binds to the IL-2 receptor, which has three forms, generated by different combinations of three different proteins, often referred to as "chains": α (alpha) (also called IL-2Rα, CD25, or Tac antigen), β (beta) (also called IL-2Rβ, or CD122), and γ (gamma) (also called IL-2Rγ, γ c, common gamma chain, or CD132); these subunits are also parts of receptors for other cytokines.
The IL-15 receptor is composed of three subunits: IL-15R alpha, CD122, and CD132.Two of these subunits, CD122 and CD132, are shared with the receptor for IL-2, but IL-2 receptor has an additional subunit ().
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2.The low affinity form is a monomer of the alpha subunit (also called CD25) and is not involved in signal transduction.
237313 Ensembl ENSG00000016402 ENSMUSG00000020007 UniProt Q9UHF4 Q6PHB0 RefSeq (mRNA) NM_001278722 NM_001278723 NM_001278724 NM_014432 NM_172786 RefSeq (protein) NP_001265651 NP_001265652 NP_001265653 NP_055247 NP_766374 Location (UCSC) Chr 6: 137 – 137.05 Mb Chr 10: 19.59 – 19.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 20 receptor, alpha subunit, is a subunit ...
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5).
3587 16154 Ensembl ENSG00000110324 ENSMUSG00000032089 UniProt Q13651 Q61727 RefSeq (mRNA) NM_001558 NM_008348 NM_001324486 RefSeq (protein) NP_001549 NP_001311415 NP_032374 Location (UCSC) Chr 11: 117.99 – 118 Mb Chr 9: 45.17 – 45.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its ...