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Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. [5] [6] [7]SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuin homolog (biological equivalent across species) in yeast (Saccharomyces cerevisiae) is Sir2.
In September 2003, Howitz and Sinclair et al. published a highly cited paper reporting that polyphenols such as resveratrol [2] activate human SIRT1 and extend the lifespan of budding yeast (Howitz et al., Nature, 2003).
[2] [3] They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. [2] Chemically, sirtuins are a class of proteins that possess either mono- ADP-ribosyltransferase or deacylase activity, including deacetylase, desuccinylase , demalonylase , demyristoylase and depalmitoylase activity.
UniProt Archive (UniParc) is a comprehensive and non-redundant database, which contains all the protein sequences from the main, publicly available protein sequence databases. [17] Proteins may exist in several different source databases, and in multiple copies in the same database.
NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. [ 5 ] [ 6 ] [ 7 ] SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent deacetylase. Studies of this protein have often been divergent, highlighting the dependence of pleiotropic effects of SIRT2 on cellular context.
Flexplay is a trademark for a discontinued DVD-compatible optical video disc format with a time-limited (usually 48-hour) playback.They are often described as "self-destructing", although the disc merely turns black or dark red and does not physically disintegrate.
Newer drives use RPC-2 firmware, which enforces DVD region coding at the hardware level. See DVD region code#Computer DVD drives for further information. Some RPC-2 drives can be converted to RPC-1 with the same features as before by using alternative firmware on the drive, or on some drives by setting a secret flag in the drive's EEPROM .
66603 Ensembl ENSG00000092208 ENSMUSG00000060121 UniProt O14893 Q9CQQ4 RefSeq (mRNA) NM_001009182 NM_001009183 NM_003616 NM_025656 RefSeq (protein) NP_001009182 NP_001009183 NP_003607 NP_079932 Location (UCSC) Chr 14: 39.11 – 39.14 Mb Chr 12: 59.06 – 59.08 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Gem-associated protein 2 (GEMIN2), also called survival of motor neuron ...