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Transcription factor II H (TF II H) is an important protein complex, having roles in transcription of various protein-coding genes and DNA nucleotide excision repair (NER) pathways. TF II H first came to light in 1989 when general transcription factor-δ or basic transcription factor 2 was characterized as an indispensable transcription factor ...
TF II F is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes. [4] [5] [6] TF II F binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TF II F stabilizes the RNA polymerase II while it's contacting TBP and TF II B.
Illustration of an activator. In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.
Transcription factor TF II A is a nuclear protein involved in the RNA polymerase II-dependent transcription of DNA. [1] TF II A is one of several general (basal) transcription factors that are required for all transcription events that use RNA polymerase II. Other GTFs include TF II D, a complex composed of the TATA binding protein TBP and TBP ...
But, the majority of TBP is present in the B-TF II D complex, which is composed of TBP and TAFII170 in a 1:1 ratio. [5] TF II D and B-TF II D are not equivalent, since transcription reactions utilizing TF II D are responsive to gene specific transcription factors such as SP1, while reactions reconstituted with B-TF II D are not. [5]
Transcription factor II E (TF II E) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. [1] It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.
The TCF/LEF family (T cell factor/lymphoid enhancer factor family) is a group of genes that encode transcription factors which bind to DNA through a SOX-like high mobility group domain. They are involved in the Wnt signaling pathway , particularly during embryonic [ 2 ] and stem-cell development, [ 3 ] but also had been found to play a role in ...
This gene encodes a multifunctional phosphoprotein, TFII-I, with roles in transcription and signal transduction. Haploinsuffiency (deletion of one copy) of the GTF2I gene is noted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.