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The most prominent side effects are dizziness and sleepiness. [44] Diphenhydramine is a potent anticholinergic agent and potential deliriant in higher doses. This activity is responsible for the side effects of dry mouth and throat, increased heart rate, pupil dilation, urinary retention, constipation, and, at high doses, hallucinations or ...
Diphenhydramine is a first-generation antihistamine and an anticholinergic drug. Anticholinergic drugs block the action of acetylcholine , a neurotransmitter in the central nervous system . [ 13 ] Studies propose that long-term use of anticholinergic drugs is associated with an increased risk for dementia among older people.
They also stated that the use of diphenhydramine in an OTC drug was illegal. [37] The FDA subsequently issued a recall for all outstanding Sominex 2 stock. [39] Television advertisements for Sominex 2 in 1983, manufactured by Beecham, made specific claims as to the effectiveness and physician preference for diphenhydramine. [40]
Naproxen/diphenhydramine (trade name Aleve PM) is a formulation of naproxen with diphenhydramine marketed by Bayer Healthcare. [1] It is made as an over-the-counter drug . The intended use of the drug is relieve pain specifically when going to sleep.
A drug combination chart designed for harm reduction by TripSit [1] Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic, recreational, or off-label indicated use of pharmaceuticals.
The consensus is to reduce dosage gradually over several weeks, e.g. 4 or more weeks for diazepam doses over 30 mg/day, [1] with the rate determined by the person's ability to tolerate symptoms. [120] The recommended reduction rates range from 50% of the initial dose every week or so, [121] to 10–25% of the daily dose every 2 weeks. [120]
Phenylephrine (10 mg/30 mL) (nasal decongestant) Alcohol (10% by volume) The LiquiCap capsule version has the following active ingredients per pill, half the recommended adult dose: Acetaminophen (325 mg/pill) (pain reliever/fever reducer) Dextromethorphan (15 mg/pill) (cough suppressant) Doxylamine succinate (6.25 mg/pill) (antihistamine/hypnotic)
Diphenhydramine is the primary constituent of dimenhydrinate and dictates the primary effect. The main differences relative to pure diphenhydramine are a lower potency due to being combined with 8-chlorotheophylline (by weight, dimenhydrinate is between 53% and 55.5% diphenhydramine) [10] and the fact that the stimulant properties of 8-chlorotheophylline help reduce the side ...