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The changes elicited by ligand binding (or signal sensing) in a receptor give rise to a biochemical cascade, which is a chain of biochemical events known as a signaling pathway. When signaling pathways interact with one another they form networks, which allow cellular responses to be coordinated, often by combinatorial signaling events. [2]
The basic unit of the Reactome database is a reaction; reactions are then grouped into causal chains to form pathways [115] The Reactome data model allows us to represent many diverse processes in the human system, including the pathways of intermediary metabolism, regulatory pathways, and signal transduction, and high-level processes, such as ...
Complex multi-component signal transduction pathways provide opportunities for feedback, signal amplification, and interactions inside one cell between multiple signals and signaling pathways. [citation needed] A specific cellular response is the result of the transduced signal in the final stage of cell signaling.
In cell biology, there are a multitude of signalling pathways. Cell signalling is part of the molecular biology system that controls and coordinates the actions of cells.. Akt/PKB signalling pathway
The upstream signaling pathway is triggered by the binding of a signaling molecule, a ligand, to a receiving molecule, a receptor. Receptors and ligands exist in many different forms, and only recognize/bond to particular molecules. Upstream extracellular signaling transduce a variety of intracellular cascades. [1]
Each neurotransmitter has very specific degradation pathways at regulatory points, which may be targeted by the body's regulatory system or medication. Cocaine blocks a dopamine transporter responsible for the reuptake of dopamine. Without the transporter, dopamine diffuses much more slowly from the synaptic cleft and continues to activate the ...
The notch/STAT3-Ser/Hes3 signaling axis is a recently identified signal transduction branch of the notch [1] signaling pathway, originally shown to regulate the number of neural stem cells in culture and in the living adult brain.
Two other dopaminergic pathways to be considered are the hypothalamospinal tract and the incertohypothalamic pathway. Parkinson's disease, attention deficit hyperactivity disorder (ADHD), substance use disorders , and restless legs syndrome (RLS) can be attributed to dysfunction in specific dopaminergic pathways.