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Granulomatous meningoencephalitis (GME) is an inflammatory disease of the central nervous system (CNS) of dogs and, rarely, cats. It is a form of meningoencephalitis. GME is likely second only to encephalitis caused by canine distemper virus as the most common cause of inflammatory disease of the canine CNS. [1]
Memantine does not undergo extensive metabolism. [9] It is negligibly metabolized by the cytochrome P450 enzymes. [8] [9] As a result, it has a decreased potential for drug interactions. [9] Metabolites of memantine include memantine glucuronide, 6-hydroxymemantine, and 1-nitrosomemantine, all of which show minimal activity as NMDA receptor ...
Up to 80 percent of dogs infected will have symptoms, but the mortality rate is only 5 to 8 percent. [5] Infectious canine hepatitis is a sometimes fatal infectious disease of the liver. [6] Canine herpesvirus is an infectious disease that is a common cause of death in puppies less than three weeks old. [7]
Skin conditions in dogs are very common, so it's important to recognize the symptoms and understand the factors that cause them. Dr. Rebecca MacMillan, a vet with over 15 years of experience, says ...
The cause is still unclear. [6] The pathogen that triggers the disease and contributes to its development has not yet been identified. It is presumed to have a multifactorial, heritable, autoimmune etiology. [2] The process is rapidly progressive, culminating in status epilepticus and ending fatally for the dog. [5]
Olney's lesions, also known as NMDA receptor antagonist neurotoxicity (NAT), is a form of brain damage consisting of selective death of neurons but not glia, observed in restricted brain regions of rats and certain other animal models exposed to large quantities of psychoactive drugs that inhibit the normal operation of the neuronal NMDA receptor.
Vets said a typical case of kennel cough is characterized by the same symptoms as this unknown illness: coughing, loss of appetite, runny nose, lethargy and sometimes a low fever. But while kennel ...
Side effects in dogs and cats include hypersalivation, diarrhea, loss of appetite, and vomiting. [12] [16] Eight percent of dogs taking maropitant at doses meant to prevent motion sickness vomited right after, likely due to the local effects maropitant had on the gastrointestinal tract. Small amounts of food beforehand can prevent such post ...