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20665 Ensembl ENSG00000100146 ENSMUSG00000033006 UniProt P56693 Q04888 RefSeq (mRNA) NM_006941 NM_011437 RefSeq (protein) NP_008872 NP_035567 Location (UCSC) Chr 22: 37.97 – 37.99 Mb Chr 15: 79.04 – 79.05 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene. Function This gene encodes a member of the ...
Mature axon tracts has been demonstrated to experience growth when mechanically stretched at the central portion of the axon cylinder. [17] Such mechanical stretch was applied by a custom axon stretch-growth bioreactor composed of four main components: custom-designed axon expansion chamber, linear motion table, stepper motor and controller. [ 17 ]
Lipofibromatosis-like neural tumor (LPF-NT) is an extremely rare soft tissue tumor first described by Agaram et al in 2016. [1] As of mid-2021, at least 39 cases of LPF-NT have been reported in the literature.
When a nerve axon is severed, the end still attached to the cell body is labeled the proximal segment, while the other end is called the distal segment. After injury, the proximal end swells and experiences some retrograde degeneration, but once the debris is cleared, it begins to sprout axons and the presence of growth cones can be detected.
Wallerian degeneration occurs after axonal injury in both the peripheral nervous system (PNS) and central nervous system (CNS). It occurs in the section of the axon distal to the site of injury and usually begins within 24–36 hours of a lesion. Prior to degeneration, the distal section of the axon tends to remain electrically excitable.
The decreased axon size reflects a higher packing density of neurofilaments in this region, which are less heavily phosphorylated and are transported more slowly. [6] Vesicles and other organelles are also increased at the nodes, which suggest that there is a bottleneck of axonal transport in both directions as well as local axonal-glial signaling.
Axon terminals (also called terminal boutons, synaptic boutons, end-feet, or presynaptic terminals) are distal terminations of the branches of an axon. An axon, also called a nerve fiber, is a long, slender projection of a nerve cell that conducts electrical impulses called action potentials away from the neuron's cell body to transmit those ...
Acrylamide intoxication resembles neural axotomy histologically and mechanically. In each case the neuron undergoes chromatolysis and atrophy of the cell body and axon. Also both seem to be mechanically related to a disruption of the delivery of neurofilament to the axon due to a decreased transport of a trophic factor from the axon to the cell ...