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CA-125 was initially detected using the murine monoclonal antibody designated OC125. Robert Bast , Robert Knapp and their research team first isolated this monoclonal antibody in 1981. [ 28 ] The protein was named "cancer antigen 125" because OC125 was the 125th antibody produced against the ovarian cancer cell line that was being studied.
CA-125 levels appear to fall during endometriosis treatment, but it has not shown a correlation with disease response. [ 121 ] Another review in 2011 identified several putative biomarkers upon biopsy, including findings of small sensory nerve fibers or defectively expressed β3 integrin subunit. [ 123 ]
Simufilam (PTI-125) is an experimental medication for the treatment of Alzheimer's disease. [ 2 ] [ 3 ] It was being developed by the American pharmaceutical firm Cassava Sciences . Development of simufilam was discontinued in November 2024 after it failed to show clinical benefit during phase III clinical trials .
In practice, the sample size used in a study is usually determined based on the cost, time, or convenience of collecting the data, and the need for it to offer sufficient statistical power. In complex studies, different sample sizes may be allocated, such as in stratified surveys or experimental designs with multiple treatment groups.
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From the 1980s to 1990's, the facility had an Intensive Treatment and Research Unit, which was a male inpatient facility for chronically ill persons with mental disabilities, and was co-sponsored by Metropolitan State Hospital and the University of California, Irvine School of Medicine. The program was a major component of research conducted by ...
Iodine-125 (125 I) is a radioisotope of iodine which has uses in biological assays, nuclear medicine imaging and in radiation therapy as brachytherapy to treat a number of conditions, including prostate cancer, uveal melanomas, and brain tumors. It is the second longest-lived radioisotope of iodine, after iodine-129.
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