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Sedation, respiratory depression and hypotension due to a reduction in systematic vascular resistance, and an increase in heart rate can occur. [23] [41] If intravenous midazolam is given too quickly, hypotension may occur. A "midazolam infusion syndrome" may result from high doses, is characterised by delayed arousal hours to days after ...
Variation in potency of certain effects may exist amongst individual benzodiazepines. Some benzodiazepines produce active metabolites. Active metabolites are produced when a person's body metabolizes the drug into compounds that share a similar pharmacological profile to the parent compound and thus are relevant when calculating how long the ...
Heart rate variability visualized with R-R interval changes Electrocardiogram (ECG) recording of a canine heart that illustrates beat-to-beat variability in R–R interval (top) and heart rate (bottom). Heart rate variability (HRV) is the physiological phenomenon of variation in the time interval between heartbeats. It is measured by the ...
This natural variation is known as heart rate variability (HRV). However, certain cardiac conditions may cause the individual IBI values to become nearly constant, resulting in the HRV being nearly zero. This can happen, for example, during periods of exercise as the heart rate increases and the beats become regular.
An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...
Midazolam is the most commonly prescribed for this use because of its strong sedative actions and fast recovery time, as well as its water solubility, which reduces pain upon injection. Diazepam and lorazepam are sometimes used. Lorazepam has particularly marked amnesic properties that may make it more effective when amnesia is the desired effect.
In most cases, vagal tone is not measured directly. Instead the processes affected by the vagus nerve – specifically heart rate and heart rate variability – are measured and used as a surrogate for vagal tone. Increased vagal tone (and thus vagal action) is generally associated with a lower heart rate and increased heart rate variability.
Examples of used parameters are blood pressure, heart rate, heart rate variability, photoplethysmography and skin conductance. Essentially, physiologic parameters are measured in order to assess sympathetic tone as a surrogate measure of stress. Intraoperative neurophysiological monitoring can also be used.