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Chiral purity is a measure of the purity of a chiral drug. Other synonyms employed include enantiomeric excess , enantiomer purity, enantiomeric purity, and optical purity. Optical purity is an obsolete term since today most of the chiral purity measurements are done using chromatographic techniques (not based on optical principles).
l-Glucose is an organic compound with formula C 6 H 12 O 6 or O=CH[CH(OH)] 5 H, specifically one of the aldohexose monosaccharides. As the l-isomer of glucose, it is the enantiomer of the more common d-glucose. l-Glucose does not occur naturally in living organisms, but can be synthesized in the laboratory.
The water-soluble MβCD is known to form soluble inclusion complexes with cholesterol, thereby enhancing its solubility in aqueous solution. MβCD is employed for the preparation of cholesterol-free products: the bulky and hydrophobic cholesterol molecule is easily lodged inside cyclodextrin rings.
Blood glucose, electrolyte and cardiac monitoring are not necessary when quinine is given by mouth. Quinine has diverse unwanted interactions with numerous prescription drugs, such as potentiating the anticoagulant effects of warfarin. [5] It is a strong inhibitor of CYP2D6, [38] an enzyme involved in the metabolism of many drugs.
A tablet is usually a compressed preparation that contains: 5-10% of the drug (active substance); 80% of fillers, disintegrants, lubricants, glidants, and binders; and; 10% of compounds which ensure easy disintegration, disaggregation, and dissolution of the tablet in the stomach or the intestine.
Chiral recognition implies the ability of chiral stationery phases to interact differently with mirror-image molecules, leading to their separation. The mechanism of enantiomeric resolution using CSPs is generally attributed to the “three-point" interaction model (fig.1.) between the analyte and the chiral selector in the stationary phase.
Glucose's low rate of glycation can be attributed to its having a more stable cyclic form compared to other aldohexoses, which means it spends less time than they do in its reactive open-chain form. [65] The reason for glucose having the most stable cyclic form of all the aldohexoses is that its hydroxy groups (with the exception of the hydroxy ...
For example, D-glucose forms an α crystal that has specific rotation of +112° and melting point of 146 °C, as well as a β crystal that has specific rotation of +19° and melting point of 150 °C. [4] The linear form does not crystallize, and exists only in small amounts in water solutions, where it is in equilibrium with the closed forms. [4]