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  2. Zinc finger transcription factor - Wikipedia

    en.wikipedia.org/wiki/Zinc_Finger_Transcription...

    Zinc finger protein transcription factors can be encoded by genes small enough to fit a number of such genes into a single vector, allowing the medical intervention and control of expression of multiple genes and the initiation of an elaborate cascade of events. In this respect, it is also possible to target a sequence that is common to ...

  3. Zinc finger - Wikipedia

    en.wikipedia.org/wiki/Zinc_finger

    Zinc fingers were first identified in a study of transcription in the African clawed frog, Xenopus laevis in the laboratory of Aaron Klug.A study of the transcription of a particular RNA sequence revealed that the binding strength of a small transcription factor (transcription factor IIIA; TFIIIA) was due to the presence of zinc-coordinating finger-like structures. [6]

  4. Kruppel-like factors - Wikipedia

    en.wikipedia.org/wiki/Kruppel-like_factors

    The C-terminal end is also highly conserved with both the first and second zinc finger have 25 amino acids, while the third has 23 amino acids. Each of the three zinc fingers recognize three unique base pairs for their DNA-binding sites, which together make the general form NCR CRC CCN (where N is any base and R is a purine).

  5. ZNF384 - Wikipedia

    en.wikipedia.org/wiki/ZNF384

    This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that ...

  6. ZFPM2 - Wikipedia

    en.wikipedia.org/wiki/ZFPM2

    The zinc finger-containing protein encoded by this gene is a widely expressed member of the FOG family of regulators of transcription factors. The family consists of the ZFPM1 and ZFPM2 genes in humans and Zfpm1 and Zfpm2 genes in mice.

  7. ZEB1 - Wikipedia

    en.wikipedia.org/wiki/ZEB1

    Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene. [5] [6] [7]ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.

  8. ZNF41 - Wikipedia

    en.wikipedia.org/wiki/ZNF41

    Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene. [3] [4]This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family.

  9. GATA zinc finger - Wikipedia

    en.wikipedia.org/wiki/GATA_zinc_finger

    In molecular biology, GATA zinc fingers are zinc-containing domains found in a number of transcription factors (including erythroid-specific transcription factor and nitrogen regulatory proteins). Some members of this class of zinc fingers specifically bind the DNA sequence (A/T)GATA(A/G) in the regulatory regions of genes ., [ 1 ] giving rise ...