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Describe in detail the pathophysiology of primary and secondary osteoarthritis. Review the components of a proper evaluation of a patient presenting with osteoarthritis, including any indicated imaging studies. Discuss the various treatment options available for osteoarthritis.
Osteoarthritis has often been referred to as a wear and tear disease. But besides the breakdown of cartilage, osteoarthritis affects the entire joint. It causes changes in the bone and deterioration of the connective tissues that hold the joint together and attach muscle to bone.
Pathophysiology of osteoarthritis. OA causes inflammation, changes in bone shape, and cartilage deterioration. It is primarily a disease affecting the cartilage. OA occurs due to...
OA is primarily a disease of cartilage. Cartilage is a unique tissue with viscoelastic and compressive properties which are imparted by its extracellular matrix, composed predominantly of type II collagen and proteoglycans.
Osteoarthritis (OA) is the most common chronic articular disease with an increasing prevalence due to population aging and obesity [1,2,3]. Osteoarthritis is characterized by articular cartilage degeneration and persistent pain, causing disability, loss of function, decreased quality of life (QoL), and economic burden [4,5,6].
Describe the pathophysiology of primary osteoarthritis. Outline the typical clinical presentation of patients with primary osteoarthritis. Review the principles in the management of primary osteoarthritis including non-medical, medical, and surgical options.
Previously thought to simply be damaged from "wear and tear," OA is now understood to be a complex interaction of local and systemic factors. This article reviews the pathology, symptoms, diagnosis, and various conservative, surgical, and novel treatments of OA.