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Hyperkeratosis can also be caused by B-Raf inhibitor drugs such as Vemurafenib and Dabrafenib. [2] It can be treated with urea-containing creams, which dissolve the intercellular matrix of the cells of the stratum corneum, promoting desquamation of scaly skin, eventually resulting in softening of hyperkeratotic areas. [3]
In a clinical setting, it manifests as a single, well-defined, skin-colored papule with a distinctive hyperkeratotic collarette at the base. [5] Though it can also be found in other places like the lower lip, nose, elbow, pre-patellar region, and periungual tissue, it mostly affects the fingers and toes. [ 6 ]
It is also typically characterized by the appearance of numerous papules. [3] Injuries can range from small to large plates composed of brown or pink, smooth or hyperkeratotic papules. [ 4 ] The most typical areas where injuries occur are the back of the feet, the toes, the legs, and the area around a venous ulcer formed in the extremities ...
The papules usually show up on the patient with an average age of 30 years. [ 1 ] [ 3 ] Kyrle disease is a rare disease unless there is a high count of patients with chronic kidney failure . The disease seems to be more prevalent in African Americans, which can be correlated to the high incidence of diabetes mellitus and kidney failure in the ...
Pinta, the least severe of the treponemal infections being limited to the skin, is thought to be transmitted by skin-to-skin contact (similar to bejel and yaws), and after an incubation period of two to three weeks, produces a raised papule, which enlarges and becomes hyperkeratotic (scaly/flaky). Lesions are usually present on the exposed ...
Porokeratosis may be divided into the following clinical types: [1]: 532 Plaque-type porokeratosis (also known as "Classic porokeratosis" and "Porokeratosis of Mibelli" [2]) is characterized by skin lesions that start as small, brownish papules that slowly enlarge to form irregular, annular, hyperkeratotic or verrucous plaques.
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A papule can be flesh colored, yellow, white, brown, black, blue or purplish, or varying shades of red. [4] [6] The intensity of redness might indicate how long the papule has been present. [6] There may be just one or many, and they may occur irregularly in different parts of the body or appear in clusters. [2] It may progress to a pustule or ...