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If there is no oxygen available for the parts of the glucose metabolism that require oxygen (citric acid cycle and oxidative phosphorylation), excess pyruvate will be converted in excess lactate. In "type B" lactic acidosis the lactate accumulates because there is a mismatch between glycolysis activity and the remainder of glucose metabolism.
It is often expressed as 85% of maximum heart rate or 75% of maximum oxygen intake. [2] When exercising at or below the lactate threshold, any lactate produced by the muscles is removed by the body without it building up. [3] The onset of blood lactate accumulation (OBLA) is often confused with the lactate threshold.
Excess post-exercise oxygen consumption (EPOC, informally called afterburn) is a measurably increased rate of oxygen intake following strenuous activity.In historical contexts the term "oxygen debt" was popularized to explain or perhaps attempt to quantify anaerobic energy expenditure, particularly as regards lactic acid/lactate metabolism; [1] in fact, the term "oxygen debt" is still widely ...
Cori cycle. The Cori cycle (also known as the lactic acid cycle), named after its discoverers, Carl Ferdinand Cori and Gerty Cori, [1] is a metabolic pathway in which lactate, produced by anaerobic glycolysis in muscles, is transported to the liver and converted to glucose, which then returns to the muscles and is cyclically metabolized back to lactate.
It was once believed that lactic acid build-up was the cause of muscle fatigue. [8] The assumption was lactic acid had a "pickling" effect on muscles, inhibiting their ability to contract. Though the impact of lactic acid on performance is now uncertain, it may assist or hinder muscle fatigue.
Anaerobic exercise is a type of exercise that breaks down glucose in the body without using oxygen; anaerobic means "without oxygen". [1] This type of exercise leads to a buildup of lactic acid. [1] In practical terms, this means that anaerobic exercise is more intense, but shorter in duration than aerobic exercise. [2] Fox and Haskell formula
VT1 is thought to reflect a person's anaerobic threshold — the point at which the oxygen supplied to the muscles no longer meets its oxygen requirements at a given work rate — and therefore lactate threshold — the point at which lactate begins to accumulate in the blood, because with ongoing dependence on anaerobic glycolysis, increasing ...
Resting skeletal muscle has a basal metabolic rate (resting energy consumption) of 0.63 W/kg [13] making a 160 fold difference between the energy consumption of inactive and active muscles. For short duration muscular exertion, energy expenditure can be far greater: an adult human male when jumping up from a squat can mechanically generate 314 ...