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Praziquantel is well absorbed (about 80%) from the gastrointestinal tract. However, due to extensive first-pass metabolism, only a relatively small amount enters systemic circulation. Praziquantel has a serum half-life of 0.8 to 1.5 hours in adults with normal renal and liver function. Metabolites have a half-life of 4 to 5 hours.
A 2022 study on the effect of heat on young people found that the critical wet-bulb temperature at which heat stress can no longer be compensated, T wb,crit, in young, healthy adults performing tasks at modest metabolic rates mimicking basic activities of daily life was much lower than the 35 °C (95 °F) usually assumed, at about 30.55 °C (86 ...
The saline cools the person's whole body by lowering the temperature of a person's blood. Catheters reduce temperature at rates ranging from 1.5 to 2 °C (2.7 to 3.6 °F) per hour. Through the use of the control unit, catheters can bring body temperature to within 0.1 °C (0.18 °F) of the target level.
Arpraziquantel ((R)-praziquantel) is the eutomer (the biologically active enantiomer) of praziquantel, and is a medication which is currently under investigation for the treatment of schistosomiasis in young children since it has less side effects than the usual racemic mixture formulation of praziquantel.
Body temperature is maintained through a balance of the heat produced by the body and the heat lost from the body. [10] Oral glass thermometer showing a body temperature in °F. Temperature can be recorded in order to establish a baseline for the individual's normal body temperature for the site and measuring conditions.
The body keeps itself normal human body temperature, near 37.6 °C (99.7 °F). Unless a needle probe can be placed with accuracy in every tumor site amenable to measurement, there is an inherent technical difficulty in how to actually reach whatever a treating center defines as an "adequate" thermal dose.
New research finds the optimal room temperature range for sleeping for older adults. Here, experts explain the best temperature for sleep.
Adjusting the human body temperature downward has been used therapeutically, in particular, as a method of stabilizing a body following trauma. It has been suggested that adjusting the adenosine A1 receptor of the hypothalamus may allow humans to enter a hibernation -like state of reduced body temperature, which could be useful for applications ...