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  2. p53 - Wikipedia

    en.wikipedia.org/wiki/P53

    p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]

  3. List of breast cancer cell lines - Wikipedia

    en.wikipedia.org/wiki/List_of_breast_cancer_cell...

    This is a list of major breast cancer cell lines that are primarily used in breast cancer research. [Notes 1] List of cell lines. Cell line Primary tumor

  4. Breast cancer classification - Wikipedia

    en.wikipedia.org/wiki/Breast_cancer_classification

    Molecular classification of breast cancer from mRNA expression profiles. DNA microarrays have compared normal cells to breast cancer cells and found differences in the expression of hundreds of genes. Although the significance of many of those genetic differences is unknown, independent analyses by different research groups has found that ...

  5. TP53BP1 - Wikipedia

    en.wikipedia.org/wiki/TP53BP1

    Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a ... 53BP1 is underexpressed in most cases of triple-negative breast cancer ...

  6. Tumor suppressor gene - Wikipedia

    en.wikipedia.org/wiki/Tumor_suppressor_gene

    Mutated p53 is involved in many human cancers, of the 6.5 million cancer diagnoses each year about 37% are connected to p53 mutations. [30] This makes it a popular target for new cancer therapies. Homozygous loss of p53 is found in 65% of colon cancers, 30–50% of breast cancers, and 50% of lung cancers.

  7. Jennifer Pietenpol - Wikipedia

    en.wikipedia.org/wiki/Jennifer_Pietenpol

    Pietenpol's early research focused on the signaling of the p53 gene within the breast cancer family, specifically Triple Negative Breast Cancer. [3] [4] [5] Pietenpol used a combined approach of bioinformatics and genetics to make discoveries on the signaling behavior of the p53 gene family. [6] [7]

  8. Inflammatory breast cancer - Wikipedia

    en.wikipedia.org/wiki/Inflammatory_breast_cancer

    Inflammatory breast cancer is a high-grade aneuploid cancer, with mutations and overexpression of p53, [13] high levels of E-cadherin and abnormal cadherin function. It is often regarded as a systemic cancer .

  9. PTEN (gene) - Wikipedia

    en.wikipedia.org/wiki/PTEN_(gene)

    5728 19211 Ensembl ENSG00000171862 ENSG00000284792 ENSMUSG00000013663 UniProt P60484 O08586 RefSeq (mRNA) NM_000314 NM_001304717 NM_001304718 NM_008960 NM_177096 RefSeq (protein) NP_000305 NP_001291646 NP_001291647 NP_000305.3 NP_032986 Location (UCSC) Chr 10: 87.86 – 87.97 Mb Chr 19: 32.73 – 32.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Space-filling model of the PTEN ...

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