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Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. [2] [3] It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning.
[42] [39] Vitamin B 12 is not one of the supplements recommended by the World Health Organization for healthy women who are pregnant, [10] however, vitamin B 12 is often suggested during pregnancy in a multivitamin along with folic acid [43] [44] especially for pregnant mothers who follow a vegetarian or vegan diet. [45]
One study in 184 premature infants, reported that individuals given monthly vitamin B 12 injections (100 μg) or taking supplements of vitamin B 12 and folic acid (100 μg/day), had higher haemoglobin concentrations after 10–12 weeks, compared to those only taking folic acid or those taking no vitamin B 12 injections. [87]
Folic acid 1 mg; Multivitamin for infusion (MVI), 1 ampule; Magnesium sulfate 3 g; The solution is typically infused over four to eight hours or as per physician's orders. [citation needed] The yellow color comes from the riboflavin in the MVI and the folic acid. [2] (The conventional composition is not optimal based on current evidence; see ...
Both high-folate diets and supplemental folic acid may help reduce the toxic side-effects of low-dose methotrexate without decreasing its effectiveness. [ 8 ] [ 9 ] Anyone taking low-dose methotrexate for the health problems listed above should consult with a physician about the need for a folic acid supplement.
They are given by injection. [2] Common side effects may include joint pain, rash, vomiting, and headache. [4] Serious side effects may include heart attacks, stroke, increased cancer growth, or pure red cell aplasia. [2] It is unclear if use is safe during pregnancy. [5] [6] They work similar to naturally occurring erythropoietin. [1]
Folic acid is a synthetic derivative of folate and is acquired by dietary supplementation. [25] Multi-vitamin dietary supplements contain folic acid as well as other B vitamins. Non-prescription folic acid is available as a dietary supplement in some countries, and some countries require the fortification of wheat flour, corn meal or rice with ...
They are taken by mouth, injection into a vein, or injection into a muscle. [12] While benefits may be seen in days, up to two months may be required until iron levels return to normal. [14] Common side effects include constipation, abdominal pain, dark stools, and diarrhea. [14]