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Thiazolidinediones may cause slight weight gain but decrease "pathologic" abdominal fat (visceral fat), and therefore may be prescribed for diabetics with central obesity. [115] Thiazolidinedione has been associated with heart failure and increased cardiovascular risk; so it has been withdrawn from the market in Europe by EMA in 2010. [116]
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It is characterized by adipose tissue accumulation predominantly around the waist and trunk. [5] Other signs of metabolic syndrome include high blood pressure, decreased fasting serum HDL cholesterol, elevated fasting serum triglyceride level, impaired fasting glucose , insulin resistance, or prediabetes.
Weight fluctuations of five pounds are more are uncommon among men. Experts explain common sudden weight gain causes, what to do, and when to see a doctor. 12 Common Causes of Sudden Weight Gain
In 2014, more than 600 million adults were obese, equal to about 13 percent of the world's adult population, [218] with that figure growing to 16% by 2022, according to the World Health Organisation [219] The percentage of adults affected in the United States as of 2015–2016 is about 39.6% overall (37.9% of males and 41.1% of females). [220]
Weight gain is an increase in body weight. This can involve an increase in muscle mass , fat deposits , excess fluids such as water or other factors. Weight gain can be a symptom of a serious medical condition.
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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.