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Cutaneous leishmaniasis is the most common form of leishmaniasis affecting humans. [4] It is a skin infection caused by a single-celled parasite that is transmitted by the bite of a phlebotomine sand fly. There are about thirty species of Leishmania that may cause cutaneous leishmaniasis.
The Franz Cell apparatus consists of two chambers separated by a membrane of animal or human skin. Human skin is preferred but due to ethical and other considerations is not always available. Human skin often may come from autopsies or plastic surgeries. [20] The test product is applied to the membrane via the top chamber.
The Draize test is an acute toxicity test devised in 1944 by Food and Drug Administration (FDA) toxicologists John H. Draize and Jacob M. Spines. Initially used for testing cosmetics, the procedure involves applying 0.5 mL or 0.5 g of a test substance to the eye or skin of a restrained, conscious animal, and then leaving it for a set amount of time before rinsing it out and recording its effects.
Some skin secretions are associated with body hair. Skin secretions originate from glands that in dermal layer of the epidermis. Sweat, a physiological aid to body temperature regulation, is secreted by eccrine glands. Sebaceous glands secrete the skin lubricant sebum. Sebum is secreted onto the hair shaft and it prevents the hair from splitting.
The Guinea pig maximisation test (GPMT) is an in vivo test to screen for substances that cause human skin sensitisation (i.e. allergens).It was first proposed by B. Magnusson and Albert Kligman in 1969 [1] and described in their 1970 book Allergic Contact Dermatitis in the Guinea Pig.
The epidermis is the outer layer of skin that keeps vital fluids in and harmful bacteria out of the body. The dermis is the inner layer of skin that contains blood vessels, nerves, hair follicles, oil, and sweat glands. [4] Severe damage to large areas of skin exposes the human organism to dehydration and infections that can result in death.
Keratinocytes form tight junctions with the nerves of the skin and hold the Langerhans cells and intra-dermal lymphocytes in position within the epidermis. Keratinocytes also modulate the immune system : apart from the above-mentioned antimicrobial peptides and chemokines they are also potent producers of anti-inflammatory mediators such as IL ...
The identification of human skin bindings has been attempted by examining the pattern of hair follicles, to distinguish human skin from that of other animals typically used for bookbinding, such as calf, sheep, goat, and pig. This is a necessarily subjective test, made harder by the distortions in the process of treating leather for binding.