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Carvacrol is present in the essential oil of Origanum vulgare (oregano), oil of thyme, oil obtained from pepperwort, and wild bergamot. [5] The essential oil of thyme subspecies contains between 5% and 75% of carvacrol, while Satureja (savory) subspecies have a content between 1% and 45%. [6]
Thymoquinone is a phytochemical compound found in the plant Nigella sativa. It is also found in select cultivated Monarda fistulosa plants which can be steam distilled to produce an essential oil. It has been classified as a pan-assay interference compound , which binds indiscriminately to many proteins. [ 1 ]
Thymol (also known as 2-isopropyl-5-methylphenol, IPMP), C 10 H 14 O, is a natural monoterpenoid phenol derivative of p-Cymene, isomeric with carvacrol.It occurs naturally in the oil of thyme, and it is extracted from Thymus vulgaris (common thyme), ajwain, [4] and various other plants as a white crystalline substance of a pleasant aromatic odor and strong antiseptic properties.
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Tegafur/gimeracil/oteracil, sold under the brand name Teysuno among others is a fixed-dose combination medication used for the treatment of advanced gastric cancer when used in combination with cisplatin, [3] and also for the treatment of head and neck cancer, colorectal cancer, non–small-cell lung, breast, pancreatic, and biliary tract cancers.
The tetrahydroisoquinoline skeleton is present in a number of drugs, [3] such as tubocurarine, one of the quaternary ammonium muscle relaxants. Drugs based on 4-substituted tetrahydroisoquinolines include nomifensine [13] and diclofensine. They can be prepared by N-alkylation of benzyl amines with haloacetophenones. [14]
Arimoclomol is believed to function by stimulating a normal cellular protein repair pathway through the activation of molecular chaperones. [medical citation needed] Since damaged proteins, called aggregates, are thought to play a role in many diseases, CytRx believes that arimoclomol could treat a broad range of diseases.
Omecamtiv mecarbil (INN [1]), previously referred to as CK-1827452, is a cardiac-specific myosin activator. It is an experimental drug being studied for a potential role in the treatment of left ventricular systolic heart failure.