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  2. RA33 - Wikipedia

    en.wikipedia.org/wiki/RA33

    RA33, also known as heterogeneous nuclear ribonucleoprotein A2/B1, is an autoantigen in human systemic autoimmune diseases. In 1989, a novel class of autoantibodies was detected in sera of patients with rheumatoid arthritis (RA), which were directed against a protein with an estimated molecular mass of 33 kDa in nuclear extracts from HeLa cells ...

  3. Anti–citrullinated protein antibody - Wikipedia

    en.wikipedia.org/wiki/Anti–citrullinated...

    Anti-CCP is also very useful in the early diagnosis of rheumatoid arthritis in high-risk groups, such as relatives of RA patients, [19] although Silman and co-workers found that the concordance rate of developing RA was 15.4% among identical (monozygotic) twins and was 3.6% among fraternal (dizygotic) twins. [20]

  4. Mutated citrullinated vimentin - Wikipedia

    en.wikipedia.org/wiki/Mutated_citrullinated_Vimentin

    Detection of autoantibodies against mutated citrullinated vimentin is part of rheumatoid arthritis (RA) diagnostics, especially in sera negative for rheumatoid factor (RF negative sera). Anti-MCV antibodies are a member of the ACPA family, a group of the so-called a ntibodies to c itrullinated p rotein/peptide a ntigens.

  5. Rheumatoid arthritis - Wikipedia

    en.wikipedia.org/wiki/Rheumatoid_arthritis

    Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. [1] It typically results in warm, swollen, and painful joints. [1] Pain and stiffness often worsen following rest. [1] Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. [1]

  6. HNRNPA2B1 - Wikipedia

    en.wikipedia.org/wiki/HNRNPA2B1

    HnRNPA2B1 is an autoantigen in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and mixed connective tissue disease. When referred to as an autoantigen, hnRNPA2B1 is also known as RA33.

  7. Autoantibody - Wikipedia

    en.wikipedia.org/wiki/Autoantibody

    Autoantibody tests may be ordered as part of an investigation of chronic progressive arthritis type symptoms and/or unexplained fevers, fatigue, muscle weakness and rashes. The antinuclear antibody (ANA) test is often ordered first.

  8. FSTL1 - Wikipedia

    en.wikipedia.org/wiki/FSTL1

    This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [ 7 ] FSTL1 up-regulates proinflammatory mediators important in the pathology of arthritis, and serum levels of FSTL1 correlate with severity of arthritis.

  9. Citrullination - Wikipedia

    en.wikipedia.org/wiki/Citrullination

    In rheumatoid arthritis and other autoimmune diseases, such as psoriatic arthritis, systemic lupus erythematosus and Sjögren's syndrome, autoantibodies often attack citrullinated proteins. The presence of anti-citrullinated protein antibody is a standard test for rheumatoid arthritis, and it is associated with more severe disease.

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