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Most patients (over 80%) have vascular symptoms and Raynaud's phenomenon, which leads to attacks of discoloration of the hands and feet in response to cold. Raynaud's normally affects the fingers and toes. Systemic scleroderma and Raynaud's can cause painful ulcers on the fingers or toes, which are known as digital ulcers.
Scleroderma is also associated with an increased risk of cardiovascular disease. [ 46 ] According to a study of an Australian cohort, between 1985 and 2015, the average life expectancy of a person with scleroderma increased from 66 years to 74 years (the average Australian life expectancy increased from 76 to 82 years in the same period).
Diabetes, for example, is the leading cause of new cases of blindness in those aged 20–74, with ocular manifestations such as diabetic retinopathy and macular edema affecting up to 80% of those who have had the disease for 15 years or more.
The decision lends new credibility to vaping companies’ longstanding argument that their products can help blunt the toll of smoking, which is blamed for 480,000 U.S. deaths annually due to ...
Including the four authorized Friday, the FDA has authorized the sale of only 27 e-cigarette products. All other products have been tobacco flavored, which isn’t widely used by young people.
People with scleromyositis have symptoms of both systemic scleroderma and either polymyositis or dermatomyositis, and is therefore considered an overlap syndrome. Although it is a rare disease, it is one of the more common overlap syndromes seen in scleroderma patients, together with MCTD and Antisynthetase syndrome .
According to the study, 75 percent of flavored e-cigarettes and their refill liquids were found to contain Diacetyl, "a flavoring chemical linked to cases of severe respiratory disease" such as ...
Pianissimo Peche Menthol: November 1, 2010: Still available: 450 Yen: 1 mg' 0,1 mg: D-spec product, changed to 'Pianissimo Eye Scene Menthol One' in mid January 2012 (Strong Menthol) Pianissimo Vive Menthol: November 1, 2011: May 2014: 450 Yen: 6 mg' 0,5 mg: D-spec product (refreshing menthol of mint type → strong menthol with moderate sweetness)