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Astaxanthin is used as a dietary supplement for human, animal, and aquaculture consumption. [3] Astaxanthin from algae, synthetic and bacterial sources is generally recognized as safe in the United States. [11] The US Food and Drug Administration has approved astaxanthin as a food coloring (or color additive) for specific uses in animal and ...
Eric A. Johnson is a microbiologist and an academic.He is a retired Professor of Bacteriology from the University of Wisconsin-Madison, serving from 1985 to 2020. [1]Johnson, most known for his research on Clostridium botulinum and its neurotoxins in food and industrial microbiology, has developed physiochemical-based methods for basic and applied research of Clostridium botulinum and ...
There can be many years between promising laboratory work and the availability of an effective anti-cancer drug: Monroe Eliot Wall discovered anti-cancer properties in Camptotheca in 1958, but it was not until 1996 – after further research and rounds of clinical trials – that topotecan, a synthetic derivative of a chemical in the plant, was ...
Cancer research is research into cancer to identify causes and develop strategies for prevention, diagnosis, treatment, and cure. Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatments.
6-Diazo-5-oxo-L-norleucine (DON) is a glutamine antagonist, which was isolated originally from Streptomyces in a sample of Peruvian soil.This diazo compound is biosynthesized from lysine by three enzymes in bacteria. [2]
Crocin has also shown antiproliferative action against cancer cells in vitro. [18] [19] [20] and in vivo. [21] Crocin through the PI3K/AKT/mTOR, MAPK, VEGF, Wnt/β-catenin, and JAK-STAT suppression has antiproliferative properties. Also, the Nrf2 and p53 signaling pathway activation may be effective in the antiproliferative effect of crocin. [22]
Astaxanthin – Anthocyanins: 8.5 fold improvement in pharmacokinetics over the complex-free anthocyanins Lycopene – 50 mg phosphatidylcholine: improvement of lycopene pharmacokinetics by 8 fold in patients with coronary heart disease [ 46 ]
Due to the nature of canthaxanthin, relative to astaxanthin (a carotenoid of significant commercial value) these beta-carotene ketolase proteins have been studied extensively. [ 16 ] [ 17 ] An E. coli based production system has been developed, that achieved canthanaxanthin production at 170 mg/L in lab scale fermentation.
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