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Intensive insulin therapy or flexible insulin therapy is a therapeutic regimen for diabetes mellitus treatment. This newer approach contrasts with conventional insulin therapy. Rather than minimize the number of insulin injections per day (a technique which demands a rigid schedule for food and activities), the intensive approach favors ...
According to the carbohydrate–insulin model, low-carbohydrate diets would be the most effective in causing long-term weight loss. Notable proponents of the carbohydrate–insulin model include Gary Taubes and David Ludwig. [1] [2] The CIM has been tested in mice [3] and humans. [4]
First described in 1934, [59] what physicians typically refer to as sliding-scale insulin (SSI) is fast- or rapid-acting insulin only, given subcutaneously, typically at meal times and sometimes bedtime, [60] but only when blood glucose is above a threshold (e.g. 10 mmol/L, 180 mg/dL). [61]
A Cochrane systematic review from 2011 showed that treatment with Sulfonylureas did not improve control of glucose levels more than insulin at 3 nor 12 months of treatment. [28] This same review actually found evidence that treatment with Sulfonylureas could lead to earlier insulin dependence, with 30% of cases requiring insulin at 2 years. [28]
The primary treatment for insulin resistance is exercise and weight loss. [59] Both metformin and thiazolidinediones improve insulin sensitivity. Metformin is approved for prediabetes and type 2 diabetes and has become one of the more commonly prescribed medications for insulin resistance. [60]
[32] [33] Liraglutide was approved by the FDA in 2019, for treatment of children ten years or older with type 2 diabetes, making it the first non-insulin drug approved to treat type 2 diabetes in children since metformin was approved in 2000. [34] Novo Nordisk made deals with generic manufacturers to enter the United States market in 2024.
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- 959 E Johnstown Rd., Gahanna, OH · Directions · (614) 636-4609