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The name "Werlhof's disease" was used more widely before the current descriptive name became more popular. [ 67 ] [ 68 ] Platelets were described in the early 19th century, and in the 1880s several investigators linked the purpura with abnormalities in the platelet count.
The skin weighs an average of four kilograms, covers an area of two square metres, and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue. [1] The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin. [3]
Purpura (/ ˈ p ɜːr p jʊər ə / [1]) is a condition of red or purple discolored spots on the skin that do not blanch on applying pressure. The spots are caused by bleeding underneath the skin secondary to platelet disorders, vascular disorders, coagulation disorders, or other causes. [2]
The preceder to IC T C P, Ebner & Fairchild IPT color appearance model (1998), has a mostly similar transformation pipeline of input → LMS → nonlinearity → IPT. [3] [9] The differences are that it defines its input to the more general CIEXYZ tristimulus color space and as a result has a more conventional Hunt-Pointer-Estevez (for D65) matrix for LMS.
PVA usually has an underlying cause, attributed to existing skin diseases and disorders associated with a cutaneous lymphoma or inflammation. [5] Mycosis fungoides is the common lymphoma believed to cause PVA, although it may be considered a precursor when the lymphoma is occult (hidden) and undiagnosed. [ 5 ]
Pigmentation disorders are disturbances of human skin color. [1] There may be a loss or reduction, which may be related to loss of melanocytes or the inability of melanocytes to produce melanin or transport melanosomes correctly. [1] Most pigmentation disorders involve the underproduction or overproduction of melanin. [2] [3]
This is an accepted version of this page This is the latest accepted revision, reviewed on 28 January 2025. "Skin pigmentation" redirects here. For animal skin pigmentation, see Biological pigment. Extended Coloured family from South Africa showing some spectrum of human skin coloration Human skin color ranges from the darkest brown to the lightest hues. Differences in skin color among ...
Specifically, evaluating the skin's color and the spread of purpura is crucial. Skin biopsies of retiform purpura can be instrumental in diagnosing suspected retiform purpura, specifically a punch or an excisional wedge biopsy. If infection is suspected, a tissue culture with initial lab workup. [citation needed]